Related Patent Info
COMPOSITIONS AND METHODS FOR PRODUCING MEGAKARYOCYTES
|THON, Jonathan, etc.
|PLATELET BIOGENESIS, INC.
|Title of Invention
|COMPOSITIONS AND METHODS FOR PRODUCING MEGAKARYOCYTES
Provided is a method for megakaryocyte production, comprising steps of (i) expanding pluripotent stem cells under low adherent or non-adherent conditions and under agitation wherein expanded pluripotent stem cells form self-aggregating spheroids, (ii) differentiating the pluripotent cells in a first culture medium into hemogenic endothelial cells, and (iii) differentiating the hemogenic endothelial cells in a second culture medium into megakaryocytic progenitors.