Related Patent Info
COMPOSITIONS AND METHODS FOR PRODUCING MEGAKARYOCYTES
| Inventor | THON, Jonathan, etc. |
|---|---|
| Assignee | PLATELET BIOGENESIS, INC. |
| Title of Invention | COMPOSITIONS AND METHODS FOR PRODUCING MEGAKARYOCYTES |
| Abstract | Provided is a method for megakaryocyte production, comprising steps of (i) expanding pluripotent stem cells under low adherent or non-adherent conditions and under agitation wherein expanded pluripotent stem cells form self-aggregating spheroids, (ii) differentiating the pluripotent cells in a first culture medium into hemogenic endothelial cells, and (iii) differentiating the hemogenic endothelial cells in a second culture medium into megakaryocytic progenitors. |