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Method for producing nephron progenitor cells

Ref. No. AJ212
Appl. No. (filing date) PCT/JP2020/016969 (2020/04/17)
Pub. No. (Pub. date) WO2020/213734 (2020/10/22)
Priority claim No. (Priority date)

JP2019-080272 (2019/04/19)

Patent No.

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Inventor OSAFUNE Kenji, etc.
Assignee Kyoto University
Title of Invention Method for producing nephron progenitor cells
Abstract

This invention relates to an efficient and stable method for producing nephron precursors or nephron organoids through a stepwise differentiation of pluripotent stem cells. More specifically, the invention is characterized by including the following two novel methods: (1) a method for producing late presomitic mesoderm cells, comprising a step of culturing presomitic mesoderm cells in a medium containing a specified set of growth factors and small molecule inhibitors; and (2) a method for producing posterior intermediate mesoderm cells, comprising a step of culturing late presomitic mesoderm cells in a medium containing a specified set of growth factors.

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