Patent Portfolio
Neurotoxicity evaluation model system using diseased iPS cell, and use thereof
| Ref. No. | AJ157 |
|---|---|
| Appl. No. （filing date） |
PCT/JP2018/017828（2018/5/8） |
| Pub. No. （Pub. date） |
WO2018/207789（2018/11/15） |
| Priority claim No. （Priority date） |
JP2017-093450 (2017/5/9) |
| Patent No. | - |
| Inventor | INOUE Haruhisa, etc. |
| Assignee | Kyoto University |
| Title of Invention | Neurotoxicity evaluation model system using diseased iPS cell, and use thereof |
| Abstract | Provided is a method for evaluating the neurotoxicity of a compound by use of neurons differentiated from an iPS cell derived from a Charcot-Marie-Tooth disease (CMT) patient. This invention is based on a finding that the neurons from a CMT patient was more susceptible than neurons from a control subject, in terms of mitochondrial aggregation in a neurite after exposure to anti-cancer drugs which are known to cause neurotoxicity in humans. |
| Comments |
- |
| Updated date | 2018/12/18 |
| Information (External link) |
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2018-207789/E90C2868C9861F7FBDA6E330186D953F74C7BF459D917D27E640CD6471A325EB/50/en |
| Tag | Nerve (Neuron) |