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Maintenance-and-amplification method and differentiation induction method for primordial germ cells/primordial germ cell-like cells

Ref. No. AJ197
Appl. No. (filing date) PCT/JP2018/045011 (2018/11/30)
Pub. No. (Pub. date) WO2019/107576 (2019/06/06)
Priority claim No. (Priority date)

JP2017-231294 (2017/11/30)

Patent No.

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Inventor SAITOU, Mitinori, etc.
Assignee Kyoto University
Title of Invention Maintenance-and-amplification method and differentiation induction method for primordial germ cells/primordial germ cell-like cells
Abstract

Present invention provides a maintenance and amplification method of PGC/PGCLC comprising a step of culturing PGC/PGCLC in the presence of a PDE 4 inhibitor and/or cyclosporin A, and preferably in the additional presence of forskolin. The invention further provides a method for inducing differentiation of the PGC/PGCLC thus maintained and amplified into oocytes in the presence of BMP and retinoic acid.

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Updated date 2019/07/19
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