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Pluripotent stem cell for neuronal differentiation induction

Ref. No. AJ105
Appl. No.
(filing date)
PCT/JP2014/058142(2014/3/24)
Pub. No.
(Pub. date)
WO2014/148646(2014/9/25)
Priority claim No.
(Priority date)

JP2013-058922 (2013/3/21)
JP2013-159375 (2013/7/31)
JP2014-005507 (2014/1/15)

Patent No.

JP6473077

Inventor INOUE Haruhisa, etc.
Assignee Kyoto University
Title of Invention Pluripotent stem cell for neuronal differentiation induction
Abstract

Provided is a method for efficiently producing synchronized motor neurons from pluripotent stem cells comprising performing the following steps (1) and (2) in this order: (1) a step for introducing into the pluripotent stem cells a nucleic acid that encodes Lhx3, Ngn2, and Isl1; and (2) a step for maintaining the expression of Lhx3, Ngn2, and Isl1 for three days or more.

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Updated date 2019/7/12
Information
(External link)
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2014-148646/5AC65B5B5E783E768BF5CAFFB8D4ACEB17816E318280350212F10552EC381721/50/en
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