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Method for isolating ureteric bud tip cells

Ref. No. AJ219
Appl. No. (filing date) PCT/JP2020/037329 (2020/09/30)
Pub. No. (Pub. date) WO2021/66076 (2021/04/08)
Priority claim No. (Priority date)

JP2019-181593(2019/10/01)

Patent No.

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Inventor OSAFUNE Kenji, etc.
Assignee Kyoto University
Title of Invention Method for isolating ureteric bud tip cells
Abstract

Provided is a method for isolating ureteric bud tip cells, which are thought to be self-renewing stem cells of urinary buds and serve as the progenitors for all cell types of the collecting duct, comprising the steps of: (1) bringing cells, tissues, or organoids which contain the ureteric bud tip cells into contact with a very-low-density lipoprotein receptor (VLDL-R) binding substance; and (2) isolating the ureteric bud tip cells by using said binding substance as an index.

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