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Method and kit for promoting proliferation of pancreatic endoderm cells

Ref. No. AJ237
Appl. No. (filing date) JP2021-005958 (2021/01/18)
Pub. No. (Pub. date) JP2021-112185 (2021/08/05)
Priority claim No. (Priority date)

US 62/962,186 (2020/01/17)

Patent No.

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Inventor KAWAGUCHI Yoshiya, etc.
Assignee Kyoto University
Title of Invention Method and kit for promoting proliferation of pancreatic endoderm cells
Abstract

Provided is a method of promoting proliferation of PDX1 positive NKX6.1 positive pancreatic endoderm cells, comprising bringing said PDX1 positive NKX6.1 positive cells into contact with a FOXO1 inhibitor and/or a Wnt signal activator. The method enables an efficient production from pluripotent stem cells of pancreatic endocrine cells, such as insulin-secreting cells, which are derived from PDX1 positive NKX6.1 positive pancreatic endoderm cells.

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