Patent Portfolio
Medium for culturing and expanding nephron progenitor cells, method for culturing and expanding nephron progenitor cells, and method for producing renal organoids
| Ref. No. | AJ235 |
|---|---|
| Appl. No. （filing date） |
PCT/JP2020/047504（2020/12/18） |
| Pub. No. （Pub. date） |
WO2021/125340（2021/6/24） |
| Priority claim No. （Priority date） |
US 62/950,120(2019/12/19) |
| Patent No. | - |
| Inventor | OSAFUNE Kenji, etc. |
| Assignee | Kyoto University |
| Title of Invention | Medium for culturing and expanding nephron progenitor cells, method for culturing and expanding nephron progenitor cells, and method for producing renal organoids |
| Abstract | Provided is a medium for culturing and expanding nephron progenitor cells, containing FGF2, heparin, a ROCK inhibitor, a GSK3β inhibitor, leukemia inhibitory factor (LIF), an ALK inhibitor, a BMP inhibitor, and a JAK inhibitor. The invention also relates to the method for culturing and expanding nephron progenitor cells by using said medium, and further to the method for producing renal organoids from the expanded nephron progenitor cells. The method of the invention contributes to reduction of culture cost, since the method does not require expensive BMP7 which has been used in all the methods ever reported for expanding nephron progenitor cells. |
| Comments |
- |
| Information (External link) |
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2021-125340/81DDB2208870D8CB891D48F2EF6A45195C6EBF35204405C64539D1899867E93E/50/en |