Mature-cardiomyocyte production method
|Appl. No. (filing date)||PCT/JP2021/007466 (2021/02/26)|
|Pub. No. (Pub. date)||WO2021/172542 (2021/09/02)|
|Priority claim No. (Priority date)||
|Inventor||YOSHIDA Yoshinori, etc.|
|Title of Invention||Mature-cardiomyocyte production method|
Provided is a method for efficiently obtaining mature cardiomyocytes usable for drug screening and transplantation therapy from immature cardiomyocytes in a short period of time, the method comprising a step of increasing the expression level of cyclin-dependent kinase inhibitor 1 in immature cardiomyocytes. According to the invention, especially when combined with the differentiation from pluripotent stem cells, mature cardiomyocytes can be produced easily and in large quantities.