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Mature-cardiomyocyte production method

Ref. No. AJ233
Appl. No. (filing date) PCT/JP2021/007466 (2021/02/26)
Pub. No. (Pub. date) WO2021/172542 (2021/09/02)
Priority claim No. (Priority date)


Patent No.


Inventor YOSHIDA Yoshinori, etc.
Assignee Kyoto University
Title of Invention Mature-cardiomyocyte production method

Provided is a method for efficiently obtaining mature cardiomyocytes usable for drug screening and transplantation therapy from immature cardiomyocytes in a short period of time, the method comprising a step of increasing the expression level of cyclin-dependent kinase inhibitor 1 in immature cardiomyocytes. According to the invention, especially when combined with the differentiation from pluripotent stem cells, mature cardiomyocytes can be produced easily and in large quantities.



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