Patent Portfolio

Method of efficiently establishing induced pluripotent stem cells

Ref. No. AJ018
Appl. No.
（filing date）		 PCT/JP2010/063733（2010/8/6）
Pub. No.
（Pub. date）		 WO2011/016588（2011/2/10）
Priority claim No.
（Priority date）

US 61/232,402　(2009/8/7)
US 61/307,306　(2010/2/23)
Patent No.

JP5376478
US8900871
US9404124
EP2462225
Inventor OKITA Keisuke, etc.
Assignee Kyoto University
Title of Invention Method of efficiently establishing induced pluripotent stem cells
Abstract

This invention, in one major embodiment, relates to a method for producing an iPS cell, which comprises bringing a somatic cell into contact with a combination of (a) Oct3/4 or a nucleic acid encoding the same, (b) Klf4 or a nucleic acid encoding the same, and (c) Sox2 or a nucleic acid encoding the same, as well as (d1) L-Myc or a nucleic acid encoding the same and/or (d2) a functional inhibitor of p53. Preferably, the reprogramming factors are introduced into a somatic cell by means of an episomal vector, especially of the early self-removal type, containing loxP sequences.
Comments

・This application is still in the international phase.
・The invention enables the efficient establishment of a safe human iPS cell suitable for clinical applications.
Updated date 2019/7/12
Information
(External link)		 https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2011-016588/BC660A11F66B7EDE2B82A39D9328C3E30289C94D1F3AB8E68149844DB2D54520/50/en
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