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Method of making induced pluripotent stem cells

Ref. No. AJ005
Appl. No.
（filing date）		 PCT/JP2009/058873（2009/5/1）
Pub. No.
（Pub. date）		 WO2009/133971（2009/11/5）
Priority claim No.
（Priority date）

US 61/071,508　(2008/5/2)
US 61/136,246　(2008/8/21)
US 61/136,615　(2008/9/19)
US 61/193,363　(2008/11/21)
Patent No.

JP5346925
US9499797
EP2268809
Inventor YAMANAKA Shinya, etc.
Assignee Kyoto University
Title of Invention Method of making induced pluripotent stem cells
Abstract

Invention relating to a method of producing iPS cells, comprising the step of introducing a non-viral expression vector (preferably a plasmid vector) incorporating at least one gene that encodes a reprogramming factor into a somatic cell. iPS cells wherein nuclear reprogramming factors are not incorporated into the chromosome can be produced by the method of this invention.
Comments

・This invention relates to a method of reprogramming somatic cells without using any viral vectors. Preferable embodiment is using plasmid vector.
・In examples of this application, three nuclear reprogramming factors (Oct3/4、Sox2 and Klf4) are incorpolated into one plasmid vector.
Updated date 2019/7/12
Information
(External link)		 https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2009-133971/CB5D4C6CCA1A7B0AD1E17DCDC0D4F5C7031614F0287AC93FD60AEAAF10B40931/50/en
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