Related Patent Info
CELLS DIFFERENTIATED FROM IMMUNOENGINEERED PLURIPOTENT CELLS
| Inventor | SCHREPFER, Sonja, etc. |
|---|---|
| Assignee | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
| Title of Invention | CELLS DIFFERENTIATED FROM IMMUNOENGINEERED PLURIPOTENT CELLS |
| Abstract | Provided is an isolated hypoimmune cardiac, endothelial, neuronal, islet, or retinal pigment cell differentiated from a hypoimmune induced pluripotent stem cell (HIP cell). HIP cells have, for example, a reduced or eliminated endogenous b-2 microglobulin (B2M) gene activity, a reduced or eliminated endogenous class II transactivator (CIITA) gene activity, and increased CD47 expression. |