Related Patent Info
|FORRESTER, Lesley, etc.
|THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
|Title of Invention
Provided is an in vitro or ex vivo method of producing a population of human pluripotent stem cell derived macrophages with an altered phenotype, comprising a step of modulating the activity of KLF1 in the population. The inventors have shown that KLF1 activation programs iPS cell-derived macrophages into cells that have an erythroblastic island-like phenotype and is able to support the maturation and enucleation of differentiating erythroid cells.