Related Patent Info
INDUCTION OF PANCREATIC BETA CELLS BY STEM CELL DIFFERENTIATION WITH RNA
| Inventor | WANG, Jiwu, etc. |
|---|---|
| Assignee | ALLELE BIOTECHNOLOGY & PHARMACEUTICALS, INC. |
| Title of Invention | INDUCTION OF PANCREATIC BETA CELLS BY STEM CELL DIFFERENTIATION WITH RNA |
| Abstract | Provided is a method for inducing differentiation of stem cells into glucose-sensing insulin-secreting pancreatic beta cells by transfecting a first combination of mRNAs (comprising FoxA2 or Sox 17), a second combination of mRNAs (comprising PDX1, Hlxb9, Ptf1a, HNF1a/b, or Sox9), and then a third combination of mRNAs (comprising PDX1, NKX6.1, NKX2.2, Pax6, Pax4, Hlxb9, or Ngn3) in the courses of differentiation. |