Related Patent Info

Provided is a spherical cell aggregate comprising a core section including a neural retina and a cover section continuously or non-continuously covering at least a portion of the surface of the core section, which is characterized in that (1) in the neural retina, a neural retina layer including at least a visual cell layer is formed, the visual cell layer includes at least one type of cells selected from the group consisting of visual cells, visual cell precursor cells, and retina precursor cells, and cells included in the visual cell layer are continuously present in a direction tangential to the surface of the core section, (2) the cover section includes retinal pigment epithelial cells that are in contact with each other, (3) the cell aggregate does not include the crystalline lens, the vitreous body, the cornea, or blood vessels, and (4) the retinal pigment epithelial cells and the neural retina layer do not together form a continuous epithelial structure; wherein the core section including neura and the retinal pigment epithelial cells of the cover section may independently be derived from pluripotent stem cells and brought in contact together to form the spherical cell aggregate of the present invention.