Related Patent Info
GENERATING HUMAN CELLS CAPABLE OF PRODUCING INSULIN IN RESPONSE TO GLUCOSE OR GLP-1
| Inventor | IKEDA, Yasuhiro, etc. |
|---|---|
| Assignee | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
| Title of Invention | GENERATING HUMAN CELLS CAPABLE OF PRODUCING INSULIN IN RESPONSE TO GLUCOSE OR GLP-1 |
| Abstract | Provided are a population of differentiated cells which produce insulin in response to glucose or GLP-1 obtained from ES cells or iPS cells, and a method for producing said cell population. The method is characterized by stepwise consecutive introduction into differentiating cells, accrding to specific differentiation stages, of three vectors comprising, respectively, nucleic acids encoding a PDX1 polypeptide, that encoding an NGN3 polypeptide, and that encoding a MAFA polypeptide. |