Related Patent Info
INDUCING MICROGLIA FROM HEMATOPOIETIC AND PLURIPOTENT STEM CELLS
|ROSSI, Derrick, etc.
|CHILDREN'S MEDICAL CENTER CORPORATION
|Title of Invention
|INDUCING MICROGLIA FROM HEMATOPOIETIC AND PLURIPOTENT STEM CELLS
Provided is a method for generating a microglia-like cell comprising steps of (i) differentiating an iPS cell (or, a hematopoietic stem cell or a CD34+ cell) into a monocyte, and (ii) differentiating the monocyte into a microglia-like cell, wherein the step (i) comprises contacting the cell with M-CSF, hSCF, Flt-3, hIL-3, or combinations thereof, and step (ii) comprises contacting the monocyte with GM-CSF and IL-34.