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The present invention provides a method for producing retinal pigment epithelial cells in a more efficient and simple manner comprising steps of; (1) culturing pluripotent stem cells for a period that does not exceed 30 days by using a medium containing at least one type of substance selected from a group consisting of FGF receptor inhibitors and MEK inhibitors, and (2) forming the retinal pigment epithelial cells by culturing the cells obtained in step (1) by using a medium containing at least one type of substance selected from a group consisting of Rho-signaling-pathway inhibitors and apoptosis inhibitors.