Related Patent Info
GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE
| Inventor | RIECK, Sebastian, etc. |
|---|---|
| Assignee | JANSSEN BIOTECH, INC. |
| Title of Invention | GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE |
| Abstract | The invention provides a method for differentiating pancreatic endoderm cells into functional beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A by use of one or more small molecule(s) selected from a defined group. The said pancreatic endoderm cells may be obtained by step-wise differentiation from pluripotent stem cells. |