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Provided is a method for producing a cell population comprising mast cells. The method comprises steps of (a) culturing a population of cells capable of differentiation into mast cells (preferably, induced pluripotent stem cells) that comprise a selectable reporter linked to Gata2 expression levels in said cells under conditions adapted to promote hematopoietic cell development, (b) isolating cells expressing Gata2, and (c) culturing said isolated cells on feeder cells, thereby obtaining a cell population comprising mast cells.