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METHOD FOR PREVENTING INCORPORATION OF UNDIFFERENTIATED IPS CELLS POSSIBLY HAVING TUMORIGENIC POTENTIAL USING DIFFERENTIATION-CONTROLLING COMPOUND

Publication No. WO2019/187918
Publication date 2019/10/03
Patent No.

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Inventor NAKASHIMA,Yoshiki, etc.
Assignee UNIVERSITY OF THE RYUKYUS
Title of Invention METHOD FOR PREVENTING INCORPORATION OF UNDIFFERENTIATED IPS CELLS POSSIBLY HAVING TUMORIGENIC POTENTIAL USING DIFFERENTIATION-CONTROLLING COMPOUND
Abstract

Provided is a medium for culturing and/or maintaining stem cells and stem cell-derived differentiated cells, which contains any one or a plurality selected from the group consisting of liarozole, piogliazone, silibinin, and chrysin as differentiation-controlling compound(s). The differentiation-controlling compound inhibits survival of undifferentiated stem cells without inducing apoptosis of differentiated cells, thus making it possible to obtain a population of differentiated cells with no incorporation of undifferentiated stem cells.

Updated date 2019/12/04
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