Patent Portfolio

Our comprehensive patent portfolio is listed here for reference.
We maintain sublicenses for numerous iPS cell-related patents and patent applications, not limited to those from Kyoto University, but also from various other universities and research institutions.

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  • Drug Discovery / Therapy

    • Nerve (Neuron)

    AJ298

    Prophylactic drug/therapeutic drug for progressive supranuclear palsy

    The invention relates to a preventive and/or therapeutic agent for progressive supranuclear palsy (hereinafter, sometimes referred to as PSP). More specifically, it relates to a preventive and/or therapeutic agent for neurodegenerative diseases including PSP, which contains as an active ingredient a growth arrest and DNA damage-inducible protein 34 (hereinafter, sometimes referred to as GADD34; also known as protein phosphatase 1 regulatory subunit 15A; hereinafter, sometimes referred to as PPP1R15A, and GADD34 and PPP1R15A may be referred to together) inhibitor, such as guanabenz.

    Pub. No.
    WO2024/195858
    Pub. date
    2024/9/26

  • Others

    AJ297

    Axioloid-based modular bottom-up in vitro model of human post-gastrulation development

    The invention relates to a three-dimensional cellular aggregate termed axioloid generated in vitro from a pluripotent stem cell and to a method for producing the same.

    Pub. No.
    WO2025/070803
    Pub. date
    2025/4/3

  • Others

    AJ296

    Target-molecule-specific functional protein control system

    Theinvention relates to a target molecule-specific functional protein control system and method.

    Pub. No.
    WO2025/100390
    Pub. date
    2025/5/15

  • Differentiation

    • Mesenchymal stem cells (MSC)

    AJ295

    Method for producing neural crest cells

    The invention relates to a method for producing neural crest cells. More specifically, it elates to a method for producing neural crest cells, which includes a step of performing suspension culture of pluripotent stem cells under specific conditions, and uses of neural crest cells obtained by the method.

    Pub. No.
    WO2024/242069
    Pub. date
    2024/11/28

  • Differentiation

    • Heart (Myocardium)

    AJ294

    Method for producing mature epicardial cell

    The invention relates to a method for producing mature epicardial cells. More specifically, it relates to a method for producing mature epicardial cells, which includes a step of culturing epicardial cells in a medium containing an mTORC2 inhibitor, and to uses of the epicardial cells obtained by this method.

    Pub. No.
    WO2025/170010
    Pub. date
    2025/8/14

  • Others

    AJ293

    CrRNA having modified nucleotide

    The invention relates to pre-crRNAs having modified nucleotides. More specifically, it relates to pre-crRNAs having specific modifications, allele-specific pre-crRNAs, and methods for producing double-stranded DNA modified cells using these pre-crRNAs.

    Pub. No.
    WO2024/204287
    Pub. date
    2024/10/3

  • Maintenance / Propagation

    • Pancreas

    AJ292

    Method for producing pancreatic endoderm cells

    The invention relates to a method for producing pancreatic endoderm cells. More specifically, it relates to a method for producing pancreatic endoderm cells, which includes a step of culturing pancreatic endoderm cells in the presence of a ROCK inhibitor, and to pancreatic endoderm cells produced by the method.

    Pub. No.
    WO2024/070494
    Pub. date
    2024/4/4

  • Isolation / Purification

    • Blood

    AJ291

    Hematopoietic stem cell screening method, hematopoietic stem cell population production method, and hematopoietic stem cell screening kit

    The invention relates to a method for selecting hematopoietic stem cells using an miRNA-responsive mRNA switch, a method for producing a hematopoietic stem cell population, and a kit for use therein.

    Pub. No.
    WO2024/242053
    Pub. date
    2024/11/28

  • Reprogramming

    AJ290

    Method for producing naïve pluripotent stem cells

    The invention relates to a method for producing naive pluripotent stem cells. In particular, it relates to a method for producing safely transplantable naïve pluripotent stem cells from primed pluripotent stem cells with high efficiency.

    Pub. No.
    WO2024/048731
    Pub. date
    2024/3/7

  • Reprogramming

    AJ289

    Method for producing primed pluripotent stem cells

    The invention relates to a method for producing primed pluripotent stem cells. More specifically, it invention relates to a method for producing primed pluripotent stem cells, which includes a step of inducing primed pluripotent stem cells from naive primate pluripotent stem cells.

    Pub. No.
    WO2024/185719
    Pub. date
    2024/9/12

  • Differentiation

    • Liver

    AJ288

    Method for producing hepatocytes

    The invention relates to a method for producing hepatocytes, hepatocytes produced by the method, and uses of the hepatocytes.

    Pub. No.
    WO2025/192601
    Pub. date
    2025/9/18

  • Differentiation

    • Heart (Myocardium)

    AJ287

    Method for producing mature cardiomyocytes

    The invention relates to a method for producing mature cardiomyocytes. More specifically, it relates to a method for producing mature cardiomyocytes, which includes a step of culturing cardiomyocytes in a medium containing an Src inhibitor, and to uses of the cardiomyocytes obtained by this method.

    Pub. No.
    WO2025/170008
    Pub. date
    2025/8/14

As for the patents and patent applications related to iPS cell technology, iPS Academia Japan, Inc. has been widely granted sublicensing rights not only from Kyoto University but also from several other universities and research institutions.
The number of patents and patent applications licensed to iPS Academia Japan, Inc. reached about 780 applications (about 200 families), of which about 520 applications have been issued as patents (in Japan, USA, Europe and other countries). (as of May 2022)

Please feel free to contact us if you are interested in such patent applications for licensing.

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Our Licensors

  • AIST
  • KWANSEI GAKUIN UNIVERSITY
  • NAGASAKI UNIVERSITY
  • Accelerate Technologies Pte Ltd
  • GIFU UNIVERSITY
  • NAGOYA CITY UNIVERSITY
  • Accellta Ltd.
  • KYOTO UNIVERSITY
  • NIHON UNIVERSITY
  • JBiC
  • KOBE UNIVERSITY
  • YOKOHAMA CITY UNIVERSITY
  • OSAKA UNIVERSITY
  • CHIBA UNIVERSITY
  • National Institutes for Quantum Science and Technology
  • OKAYAMA UNIVERSITY
  • TOKYO WOMEN'S MEDICAL UNIVERSITY
  • 　...etc