Related Patent Info
COMPOSITIONS AND METHODS FOR ENHANCING MATURATION STATES OF HEALTHY AND DISEASED CARDIOMYOCYTES
|KIM, Deok-Ho, etc.
|UNIVERSITY OF WASHINGTON
|Title of Invention
|COMPOSITIONS AND METHODS FOR ENHANCING MATURATION STATES OF HEALTHY AND DISEASED CARDIOMYOCYTES
Provided is a method for making stem cell-derived cardiomyocytes, comprising a step of contacting stem cell derived cardiomyocytes with a nanopatterned substrate, thyroid hormone T3, and a Let7i microRNA, wherein a transition of the stem cell-derived cardiomyocytes from a fetal phenotype to a more mature phenotype that more closely resembles that of adult cardiomyocytes is promoted.