Related Patent Info
IMMUNOENGINEERED PLURIPOTENT CELLS
|SCHREPFER, Sonja, etc.
|THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|Title of Invention
|IMMUNOENGINEERED PLURIPOTENT CELLS
Provided is a method for generating a hypo-immunogenic pluripotent stem cell comprising steps of (a) eliminating the activity of both alleles of B2M gene in an iPS cell, (b) eliminating the activity of both alleles of CIITA gene in said iPS cell, and (c) increasing the expression of CD47 in said iPS cell.