Related Patent Info
FEEDER-FREE DERIVATION OF HUMAN-INDUCED PLURIPOTENT STEM CELLS WITH SYNTHETIC MESSENGER RNA
| Inventor | WANG, Jiwu, etc |
|---|---|
| Assignee | ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS, INC. |
| Title of Invention | FEEDER-FREE DERIVATION OF HUMAN-INDUCED PLURIPOTENT STEM CELLS WITH SYNTHETIC MESSENGER RNA |
| Abstract | Disclosed is a kinetically controlled process for creating iPS cells, specifically relating to the use of synthetic mRNA cocktails encoding fusions between reprogramming factors with transactivation domains, e.g. an N-terminal MyoD transactivation domain. Also disclosed are methods for feeder-free and xeno-free derivation of human iPS cells using synthetic messenger RNAs. |