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APPLICATION OF INDUCED PLURIPOTENT STEM CELLS TO GENERATE ADOPTIVE CELL THERAPY PRODUCTS

Inventor COOPER, Laurence, J.N., etc
Assignee BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Title of Invention APPLICATION OF INDUCED PLURIPOTENT STEM CELLS TO GENERATE ADOPTIVE CELL THERAPY PRODUCTS
Abstract

The application of induced pluripotent stem cells (iPSCs) to generate adoptive cell therapy products and usage of iPSCs for screening potential toxicity of immune receptors are described herein. In some aspects, iPSCs and cells differentiated therefrom are provide which do not express a HLA gene (e.g., HLA-A).