Related Patent Info
METHODS FOR DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO HLA HOMOZYGOUS IMMUNE CELLS
| Inventor | VODYANYK, Maksym, A., etc. |
|---|---|
| Assignee | FUJIFILM CELLULAR DYNAMICS, INC. |
| Title of Invention | METHODS FOR DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO HLA HOMOZYGOUS IMMUNE CELLS |
| Abstract | Provided is a method for producing HLA homozygous immune cells comprising steps of (a) obtaining iPSCs, wherein the iPSCs are reprogrammed from a population of HLA homozygous blood cells, (b) differentiating the iPSCs to hematopoietic precursor cells (HPCs), and (c) culturing the HPCs under conditions to promote immune cell differentiation, thereby producing HLA homozygous immune cells. |