Related Patent Info
DIFFERENTIATION OF CORTICAL NEURONS FROM HUMAN PLURIPOTENT STEM CELLS
| Inventor | QI, Yuchen, etc. |
|---|---|
| Assignee | MEMORIAL SLOAN-KETTERING CANCER CENTER |
| Title of Invention | DIFFERENTIATION OF CORTICAL NEURONS FROM HUMAN PLURIPOTENT STEM CELLS |
| Abstract | Provided is an in vitro method for differentiating pluripotent stem cells, comprising a step of exposing stem cells to an effective concentration of one or more inhibitors of TGFβ/Activin-Nodal signaling, one or more inhibitors of BMP signaling, one or more inhibitors of Wnt signaling, one or more inhibitors of MAPK/ERK kinase signaling, one or more inhibitors of FGF signaling, and one or more inhibitors of Notch signaling, such that a plurality of the cells differentiate and express one or more cortical neuron precursor markers. |