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Provided is a method of producing iPSCs that are essentially free of reprogramming vectors, comprising steps of (a) introducing reprogramming vectors into a human somatic cell to produce the first cell population, wherein the reprogramming vectors comprises a viral origin of replication, an expression cassette encoding an iPSC reprogramming factor, a synthetic transcription factor, or both, and a suicide gene, (b) culturing the first cell population to effect expression of the reprogramming factor, the synthetic transcription factor, or both, to produce the second cell population, and (c) contacting the second cell population with a suicide gene substrate to produce iPSCs that are essentially free of reprogramming vectors.