Related Patent Info
CELL-BASED TREATMENT AND DRUG DISCOVERY IN HIRSCHSPRUNG'S DISEASE ENABLED BY PLURIPOTENT STEM CELL-DERIVED HUMAN ENTERIC NEURAL CREST LINEAGES
| Inventor | STUDER, Lorenz, etc. |
|---|---|
| Assignee | MEMORIAL SLOAN-KETTERING CANCER CENTER |
| Title of Invention | CELL-BASED TREATMENT AND DRUG DISCOVERY IN HIRSCHSPRUNG'S DISEASE ENABLED BY PLURIPOTENT STEM CELL-DERIVED HUMAN ENTERIC NEURAL CREST LINEAGES |
| Abstract | Provided is a method for inducing differentiation of stem cells, comprising contacting a population of stem cells with effective amounts of one or more inhibitor of TGFβ/Activin-Nodal signaling and one or more activator of Wnt signaling, and further contacting said population of cells with an effective amount(s) of one or more molecule that induces vagal neural crest patterning for at least about 2 days to produce a population of differentiated cells that express one or more enteric neural crest lineage marker. |