Related Patent Info
IPSC-EC PERFORMANCE ENHANCEMENT VIA SIRT1 OVEREXPRESSION
| Inventor | AMEER, Guillermo A, etc. |
|---|---|
| Assignee | NORTHWESTERN UNIVERSITY |
| Title of Invention | IPSC-EC PERFORMANCE ENHANCEMENT VIA SIRT1 OVEREXPRESSION |
| Abstract | Provided is a composition comprising iPSC-derived endothelial cells (ECs) that overexpress Sirtuin 1 (SIRT1), wherein the iPSC-derived ECs comprise exogenous nucleic acid encoding SIRT1. SIRT1 is an NAD+ dependent deacetylase involved in the regulation of cell senescence. The said iPSC-derived ECs are expected to have stable endothelial phenotypes and cell proliferative capacities over time. |