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Provided is a method for differentiating pluripotent cells into midbrain dopamine neurons comprising steps of (i) contacting a plurality of pluripotent cells with a TGFp/Activin-Nodal signaling inhibitor, a Sonic hedgehog signaling activator, and a Wnt signaling activator at incrementing concentrations such that a plurality of the cells differentiate and express FOXA2 and LMX1A, and (ii) subjecting the differentiated cells to conditions favoring maturation of the cells into dopamine neurons, for example, contacting the cells with BDNF, GDNF, cAMP, TGFP3, ascorbic acid, and/or DAP; thereby differentiating them into midbrain dopamine neurons.