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MATURATION OF MAMMALIAN HEPATOCYTES

Inventor KÜPPERS-MUNTHER, Barbara
Assignee TAKARA BIO EUROPE AB
Title of Invention MATURATION OF MAMMALIAN HEPATOCYTES
Abstract

Provided is a method for promoting maturation of mammalian hepatocytes including human iPS cell-derived hepatocytes, comprising a step of exposing said hepatocytes to at least one maturation factor selected from the group consisting of Src kinase inhibitors, vitamin D derivatives, hypoxia inducing compounds, sphingosine derivatives, PPARs activators, PAF, PKC inhibitors, and combinations thereof.