Related Patent Info

ENGINEERED ADULT-LIKE HUMAN HEART TISSUE

Inventor VUNJAK-NOVAKOVIC, Gordana, etc.
Assignee THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Title of Invention ENGINEERED ADULT-LIKE HUMAN HEART TISSUE
Abstract

Provided is a method for engineering three-dimensional functional adult cardiac tissue from iPS cell-derived cardiomyocytes comprising a step of electromechanically conditioning the derived cardiomyocytes, wherein the electromechanical conditioning includes a step of exposing the derived cardiomyocytes to electromechanical stimuli that increases in intensity over a period of time.