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Provided is a method for enhancing differentiation of multipotent stem cells and pluripotent stem cells into neurons comprising steps of seeding the cells onto a substrate patterned with nano- and/or micro-grating structures, wherein the nano- and/or micro-grating structures are selected from gratings and hierarchical gratings, wherein said hierarchical gratings comprise said gratings with secondary structures at the base of and within the grooves of said gratings, and contacting the cells with medium. In a preferred embodiment, the differentiated neurons are dopaminergic neurons.