Related Patent Info
AGE-MODIFIED CELLS AND METHODS FOR MAKING AGE-MODIFIED CELLS
| Inventor | STUDER, Lorenz, etc. |
|---|---|
| Assignee | MEMORIAL SLOAN-KETTERING CANCER CENTER |
| Title of Invention | AGE-MODIFIED CELLS AND METHODS FOR MAKING AGE-MODIFIED CELLS |
| Abstract | Provided is a method for producing a cell exhibiting one or more chronological marker comprising a step of reducing the level of genomic nucleic acid methylation in a cell that is deficient in the said chronological marker, especially wherein the said cell is a somatic cell differentiated from an iPS cell. In some embodiments, reducing the level of genomic nucleic acid methylation in the cell induces one or more chronological marker to establish a disease model of a late-onset disease. |