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Provided is a method of identifying differentiation markers, comprising steps of a) culturing a primary cell under conditions such that said primary cell de-differentiates to generate an iPSC, b) treating said iPSC under conditions such that said iPSC differentiates into a differentiated cell, and c) identifying molecular markers that are indicative of differentiation into said differentiated cell. In some preferred embodiments, the differentiated cells are pancreatic beta cells and markers of differentiation are identified and validated.