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METHODS FOR GENERATION OF PODOCYTES FROM PLURIPOTENT STEM CELLS AND CELLS PRODUCED BY THE SAME

Inventor INGBER, Donald E, etc.
Assignee PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Title of Invention METHODS FOR GENERATION OF PODOCYTES FROM PLURIPOTENT STEM CELLS AND CELLS PRODUCED BY THE SAME
Abstract

Provided is a method for generating a population of podocytes comprising steps of contacting a population of pluripotent stem cells with a podocyte induction medium comprising (i) activin A, (ii) BMP, (iii) a GSK-3 inhibitor or a Wnt activator, (iv) VEGF, and (v) retinoic acid.