Related Patent Info
INDUCED PLURIPOTENT STEM CELL AND METHOD FOR PRODUCING THE SAME
| Inventor | WU, Sen、etc. |
|---|---|
| Assignee | UNIVERSITY OF UTAH RESEARCH FOUNDATION |
| Title of Invention | INDUCED PLURIPOTENT STEM CELL AND METHOD FOR PRODUCING THE SAME |
| Abstract | Provided is an episome for inducing transgene-free and germ line competent iPS cells comprising OCT4, KLF4, SOX2, cMYC, NANOG, LIN28, and NR5A2, especially wherein preferred embodiments may contain a polycistronic locus composed of at least two of said genes, and may further contain the microRNA 302/367 gene cluster, a positive selection marker like neomycin resistance, a negative selection marker like HSV-tk, or a combination thereof. |