Related Patent Info
IN VIVO MODEL OF HUMAN SMALL INTETINE USING PLURIPOTENT STEM CELLS AND METHODS OF MAKING AND USING SAME
| Inventor | WELLS, James, M, etc. |
|---|---|
| Assignee | CHILDREN'S HOSPITAL CENTER, D/B/A CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER |
| Title of Invention | IN VIVO MODEL OF HUMAN SMALL INTETINE USING PLURIPOTENT STEM CELLS AND METHODS OF MAKING AND USING SAME |
| Abstract | Provided is a method for making a vascularized human hollow organ comprising a step of engrafting a human intestinal organoid (HIO) obtained from a human iPS cell into an immune compromised organism wherein during said engrafting step said HIO forms mature intestinal tissue. Also provided is a method for further making a human intestinal tissue containing a functional enteric nervous system (ENS) comprising a step of contacting a vagal-like neural crest cells (NCC) derived from a human iPS cell with a three dimensional HIO and transplanting said HIO in vivo. |