Related Patent Info
METHOD TO REDUCE ONCOGENIC POTENTIAL OF INDUCED PLURIPOTENT STEM CELLS FROM AGED DONORS
| Inventor | KIM, Kitai, etc |
|---|---|
| Assignee | MEMORIAL SLOAN-KETTERING CANCER CENTER |
| Title of Invention | METHOD TO REDUCE ONCOGENIC POTENTIAL OF INDUCED PLURIPOTENT STEM CELLS FROM AGED DONORS |
| Abstract | Provided is a method for improving at least one of DNA damage response, apoptosis response, genomic stability and glucose metabolism of an iPS cell derived from aged donors (A-iPSC) to levels approximating those from young donors (Y-iPSC) comprising a step of supplementing A-iPSC with at least one of (i) pluripotency factor ZSCANIO, (ii) GLUT3, and (iii) an exosome subunit, especially wherein excessive expression of GPX2 is inhibited by at least one of said supplementing. |