Related Patent Info
ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS
| Inventor | WANG, Jichang, etc. |
|---|---|
| Assignee | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN, etc. |
| Title of Invention | ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS |
| Abstract | Provided is a method for using one or more type 7 long terminal repeat (LTR7) nucleic acid sequences of type H human endogenous retroviruses (HERVH) for identifying primate naive pluripotent stem cells, wherein the LTR7/HERVH-associated transcription is used as a marker and the sequences comprise a binding motif for one or more of transcription factors selected from LBP9, Oct4, NANOG and /or Klf4. |