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PROPHYLACTIC, THERAPEUTIC, OR DIAGNOSTIC DRUG FOR ALZHEIMER'S DISEASE USING MICROORGANISM-DERIVED COMPOUND

Ref. No. AJ195
Appl. No.
（filing date）		 PCT/JP2019/016029（2019/4/12）
Pub. No.
（Pub. date）		 WO2019/198825 （2019/10/17）
Priority claim No.
（Priority date）

JP2018-077632（2018/04/13）
Patent No.

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Inventor INOUE, Haruhisa, etc.
Assignee Kyoto University
Title of Invention PROPHYLACTIC, THERAPEUTIC, OR DIAGNOSTIC DRUG FOR ALZHEIMER'S DISEASE USING MICROORGANISM-DERIVED COMPOUND
Abstract

Present invention provides a prophylactic, therapeutic, or diagnostic drug for Alzheimer's disease (AD) using a microorganism-derived compound. Specifically provided are a prophylactic or therapeutic agent for AD that includes at least one compound selected from the group consisting of Mer-A2026A, verrucarin A, kalafungin, concanamycin A, efomycin A, brefeldin A, eupenifeldin, elaiophylin, and boromycin, and a diagnostic agent for AD that includes at least one compound selected from the group consisting of the aforementioned compounds, roridin A, leucanicidin, bafilomycin A1, and bafilomycin B1. The inventors completed this invention upon finding that the aforementioned specific compounds from microorganism-derived compound libraries brought changes in the amount of Aβ42 or the ratio of Aβ42/40 in neurons differentiated from AD patient-derived iPS cells.
Information
(External link)		 https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2019-198825/6F9CB511F5E85278A6DE9AF5232D003F1145EFDE9787A442247482DA34711289/50/en
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