Patent Portfolio
Maintenance-and-amplification method and differentiation induction method for primordial germ cells/primordial germ cell-like cells
| Ref. No. | AJ197 |
|---|---|
| Appl. No. （filing date） |
PCT/JP2018/045011（2018/11/30） |
| Pub. No. （Pub. date） |
WO2019/107576（2019/6/6） |
| Priority claim No. （Priority date） |
JP2017-231294 (2017/11/30) |
| Patent No. | - |
| Inventor | SAITOU, Mitinori, etc. |
| Assignee | Kyoto University |
| Title of Invention | Maintenance-and-amplification method and differentiation induction method for primordial germ cells/primordial germ cell-like cells |
| Abstract | Present invention provides a maintenance and amplification method of PGC/PGCLC comprising a step of culturing PGC/PGCLC in the presence of a PDE 4 inhibitor and/or cyclosporin A, and preferably in the additional presence of forskolin. The invention further provides a method for inducing differentiation of the PGC/PGCLC thus maintained and amplified into oocytes in the presence of BMP and retinoic acid. |
| Comments |
- |
| Updated date | 2019/7/19 |