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Method for stepwise induction from hepatoblasts into biliary epithelial progenitor cells

Ref. No. AJ180
Appl. No.
(filing date)
PCT/JP2017/041806(2017/11/21)
Pub. No.
(Pub. date)
WO2018/097127(2018/5/31)
Priority claim No.
(Priority date)

JP2016-227128 (2016/11/22)

Patent No.

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Inventor OSAFUNE, Kenji, etc.
Assignee Kyoto University
Title of Invention Method for stepwise induction from hepatoblasts into biliary epithelial progenitor cells
Abstract

Provided is a method for producing biliary epithelial progenitor cells comprising a step of culturing hepatoblasts, which may be derived from pluripotent stem cells, in a medium containing TGFβ and EGF. The biliary epithelial progenitor cells obtained by the method include the cells in the doctal plate (DP) phase and the remodeling doctal plate (RDP) phase, which can be induced sequentially in a stepwise manner.

Comments

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Updated date 2019/6/13
Information
(External link)
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2018-097127/EB38A9CCA81815BFB17A889FF4B455AAEF551A720907B6229CCF2CC16A0526A1/50/en