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Method for inducing cerebral cortex neurons

Ref. No. AJ169
Appl. No.
(filing date)
PCT/JP2016/062578(2016/4/14)
Pub. No.
(Pub. date)
WO2016/167372(2016/10/20)
Priority claim No.
(Priority date)

JP2015-082497 (2015/04/14)

Patent No.

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Inventor TAKAHASHI, Jun, etc.
Assignee Kyoto University
Title of Invention Method for inducing cerebral cortex neurons
Abstract

Provided is a method for producing differentiation of cerebral cortex neurons from pluripotent stem cells, comprising steps of (i) suspension culture of pluripotent stem cells in a medium containing a TGFβ inhibitor, bFGF, a Wnt inhibitor, and a BMP inhibitor, (ii) suspension culture of the cells obtained in (i) in a medium containing a Wnt inhibitor and a BMP inhibitor, and (iii) further culturing the cells obtained in (ii). Subsequent to step (iii), the method may further comprise a step (4) selecting the cell which expresses at least one of the marker proteins selected from the group consisting of CD231, PCDH17 and CDH8.

Comments

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Updated date 2019/6/13
Information
(External link)
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2016-167372/BFC744ADF8EA6B8BC7EB428AE50F68CC644BA254A116FC00A2B6D0674DEEAD6B/50/en
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