Patent Portfolio
Preventive and therapeutic drug for cartilaginous hyperplasia and method of screening for the same
| Ref. No. | AJ168 |
|---|---|
| Appl. No. （filing date） |
US 14/879,507（2015/10/9） |
| Pub. No. （Pub. date） |
US 2016-0177406（2016/6/23） |
| Priority claim No. （Priority date） |
JP 2014-227500 |
| Patent No. | US9921212 |
| Inventor | TOGUCHIDA Junya, etc. |
| Assignee | Kyoto University |
| Title of Invention | Preventive and therapeutic drug for cartilaginous hyperplasia and method of screening for the same |
| Abstract | This invention has been completed based on the findings, obtained using chondrocytes differentiated from iPS cells derived from cartilaginous hyperplasia patients, that AMP/PKA/CREB signal transduction pathway is involved in the hyperplasia of cartilage tissues. Provided is a therapeutic or preventive drug for cartilaginous hyperplasia comprising an adenylate cyclase inhibitor (preferably SQ22536) which inhibits the transduction pathway, as an active ingredient. Also provided is a method for screening such a drug, comprising a step of determining CREB phosphorylation level (or, SOX9 promoter activity or cAMP level) in a chondroprogenitor cell (preferably differentiated from an iPS cell having a NLRP3 mutation) contacted with a test substance. |
| Comments |
- |
| Updated date | 2019/6/13 |
| Information (External link) |
https://www.j-platpat.inpit.go.jp/c1800/PU/JP-2014-227500/DB9FD60126A2262EDE21D055FE0BD7B9153DB2DF468BFB1150483BBA897AEB99/10/en |