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Method for inducing trophectoderm from naive pluripotent stem cells

Ref. No. AJ231
Appl. No. (filing date) PCT/JP2020/43328 (2020/11/20)
Pub. No. (Pub. date) WO2021/106765 (2021/06/03)
Priority claim No. (Priority date)

JP2019-212446(2019/11/25)

Patent No.

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Inventor TAKASHIMA Yasuhiro, etc.
Assignee Kyoto University
Title of Invention Method for inducing trophectoderm from naive pluripotent stem cells
Abstract

Provided is a method for inducing trophectoderm, which has been difficult to induce from conventional primed pluripotent stem cells, from naive pluripotent stem cells, comprising: culturing naive pluripotent stem cells in a medium containing two or more kinds selected from a TGFβ inhibitor, an MEK inhibitor, BMP, and a JAK inhibitor to induce differentiation into trophectoderm.

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