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Method for inducing trophectoderm from naive pluripotent stem cells

Ref. No. AJ231
Appl. No.
(filing date)
PCT/JP2020/43328(2020/11/20)
Pub. No.
(Pub. date)
WO2021/106765(2021/6/3)
Priority claim No.
(Priority date)

JP2019-212446(2019/11/25)

Patent No.

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Inventor TAKASHIMA Yasuhiro, etc.
Assignee Kyoto University
Title of Invention Method for inducing trophectoderm from naive pluripotent stem cells
Abstract

Provided is a method for inducing trophectoderm, which has been difficult to induce from conventional primed pluripotent stem cells, from naive pluripotent stem cells, comprising: culturing naive pluripotent stem cells in a medium containing two or more kinds selected from a TGFβ inhibitor, an MEK inhibitor, BMP, and a JAK inhibitor to induce differentiation into trophectoderm.

Comments

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Information
(External link)
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2021-106765/4F385AE8E9E1447CF70ACBBDF00C6699EC727F9D43264B75D94CCE46EF53FCA6/50/en