Patent Portfolio
Cilia-related disease model and use thereof
| Ref. No. | AJ216 |
|---|---|
| Appl. No. （filing date） |
PCT/JP2020/028474（2020/7/22） |
| Pub. No. （Pub. date） |
WO2021/15245（2021/1/28） |
| Priority claim No. （Priority date） |
JP2019-135634(2019/07/23) |
| Patent No. | - |
| Inventor | OSAFUNE Kenji, etc. |
| Assignee | Kyoto University |
| Title of Invention | Cilia-related disease model and use thereof |
| Abstract | The invention relates to a renal cyst-forming model obtained from a renal organoid induced from an iPS cell derived from a patient with a cilia-related disease such as autosomal dominant polycystic kidney (ADPKD), and a method for screening or evaluating a therapeutic agent for cilia-related diseases using the same, wherein the cyst-formation is promoted by culturing in the presence of forskolin or Blebbistatin, etc. The renal cyst-forming model of the invention recapitulates the cilia-related disease phenotype such as cyst formation and decreased calcium release, and thus enables an efficient and highly accurate screening and evaluation of candidate therapeutic agents for cilia-related diseases such as ADPKD by using as indices the morphology of renal cysts and calcium kinetics. |
| Comments |
- |
| Information (External link) |
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2021-015245/CFA5603989C3B0EF7DEFEE738E9EF580C3A6256EE6B68E3ABFE53A9C6AFA4334/50/en |