Prophylactic and/or therapeutic agent for amyotrophic lateral sclerosis
|Appl. No. (filing date)||PCT/JP2018/043242 (2018/11/22)|
|Pub. No. (Pub. date)||WO2019/103109 (2019/05/31)|
|Priority claim No. (Priority date)||
|Inventor||INOUE, Haruhisa, etc.|
|Title of Invention||Prophylactic and/or therapeutic agent for amyotrophic lateral sclerosis|
The present invention provides a prophylactic and/or therapeutic agent for ALS that comprises an Src/c-Abl pathway inhibitor. The present inventors found that the Src/c-Abl kinase pathway is a potential therapeutic target of ALS through screening of a chemical library of known compounds on an assay with motor neurons differentiated from SOD1-related ALS patient-derived iPS cells.